Fecal immunochemical test for hemoglobin versus fecal calprotectin to monitor endoscopic activity in inflammatory bowel disease
Rev. esp. enferm. dig
; 115(10): 553-558, 2023. tab, graf
Article
in En
| IBECS
| ID: ibc-226626
Responsible library:
ES1.1
Localization: ES15.1 - BNCS
ABSTRACT
Aim:
endoscopy identifies inflammatory activity, however, it is an unpleasant test and is not always accessible. The aim of the study was to compare the usefulness of quantitative fecal immunochemical test (FIT) versus fecal calprotectin (FC) to determine endoscopic activity in patients with inflammatory bowel disease (IBD).Methods:
cross-sectional prospective observational study. The stool samples were collected within three days before starting the preparation for the colonoscopy. We used the Mayo index for ulcerative colitis (UC) and the simplified endoscopic index for Crohns disease (CD). Mucosal healing (MH) was defined as the score 0 points in each of the endoscopic indices.Results:
eighty-four patients were included, 40 (47.6 %) with UC. In patients with IBD, FIT and FC showed a significant correlation with the presence of inflammatory activity/MH on endoscopy, with no statistically significant differences between the two receiver-operating characteristic (ROC) curves. Both tests improved their diagnostic performance when assessing patients with UC; the Spearman correlations between FIT and FC and endoscopic inflammatory activity were r = 0.6 (p = 0.0001) and r = 0.7 (p = 0.0001), respectively. In Crohns disease, the diagnostic utility of both tests was lower.Conclusions:
FIT is an alternative to monitor endoscopic activity among ulcerative colitis patients. In Crohns disease, more studies are needed to determine the role of fecal biomarkers. (AU)Key words
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Collection:
06-national
/
ES
Database:
IBECS
Main subject:
Hemoglobins
/
Immunochemistry
/
Inflammatory Bowel Diseases
/
Endoscopy
Limits:
Humans
Language:
En
Journal:
Rev. esp. enferm. dig
Year:
2023
Document type:
Article